Bacterial Endotoxins Testing Services

The Bacterial Endotoxins Test (BET), commonly known as the Limulus Amebocyte Lysate (LAL) test, is a vital microbiological assay used to detect and measure endotoxins—harmful substances found in the outer membrane of Gram-negative bacteria. These endotoxins can trigger serious inflammatory reactions, including fever, shock, or even organ failure when introduced into the human body.

BET is routinely performed on pharmaceutical products, biologicals, and medical devices, especially those intended for injection or direct contact with blood or internal tissues. The test uses the blood cells of the horseshoe crab (Limulus polyphemus), which react in the presence of endotoxins, allowing accurate detection and quantification.

Controlling endotoxin levels is critical to ensure patient safety and regulatory compliance. The BET is recognized by pharmacopeias worldwide (e.g., USP, EP, JP) and is an essential step in quality control to prevent contamination and ensure the sterility and safety of healthcare products.