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Acute irritation toxicity studies are conducted to assess whether a substance causes reversible damage to the skin, eyes, or respiratory tract after a single or short-term exposure. These studies are crucial in evaluating the safety of chemicals, pharmaceuticals, cosmetics, and various consumer products.
They help determine the irritation potential, which guides product labeling, handling precautions, and regulatory classification.
Key Aspects Assessed in Acute Irritation Studies:-
Skin irritation – redness, swelling, or damage to the skin surface
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Eye irritation – tearing, redness, corneal damage, or visual impairment
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Respiratory irritation – coughing, wheezing, or discomfort in the nose and throat
These studies are typically performed using in vitro or in vivo models, depending on regulatory requirements. Results play a vital role in ensuring user safety and complying with global safety regulations before a product is approved for market use.
